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  <xs:element id="vcyt_HeadquartersAndLaboratoryFacilitiesSouthSanFranciscoSanDiegoAndAustinMember" abstract="true" name="HeadquartersAndLaboratoryFacilitiesSouthSanFranciscoSanDiegoAndAustinMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="vcyt_StockIssuedAndSoldDuringPeriodSharesInPrivatePlacement" abstract="false" name="StockIssuedAndSoldDuringPeriodSharesInPrivatePlacement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
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  <xs:element id="vcyt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsInitialGrants" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsInitialGrants" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
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  <xs:element id="vcyt_BusinessCombinationContingentConsiderationLiabilityFairValueAdjustment" abstract="false" name="BusinessCombinationContingentConsiderationLiabilityFairValueAdjustment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="vcyt_ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodForWhichDirectorHasToServeAsBoardOfDirectorToReceiveGrantToPurchaseShares" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodForWhichDirectorHasToServeAsBoardOfDirectorToReceiveGrantToPurchaseShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="vcyt_DebtInstrumentEndOfTermPaymentInterestAmount" abstract="false" name="DebtInstrumentEndOfTermPaymentInterestAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcyt_BiopharmaceuticalAndOtherCollaborationMilestonesMember" abstract="true" name="BiopharmaceuticalAndOtherCollaborationMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcyt_AuditorInformationAbstract" abstract="true" name="AuditorInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="vcyt_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumValueOfSharesPerEmployee" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumValueOfSharesPerEmployee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcyt_BusinessAcquisitionNonvestedAquireeAwardsModifiedFairValue" abstract="false" name="BusinessAcquisitionNonvestedAquireeAwardsModifiedFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="vcyt_DebtInstrumentEarlyTerminationFee" abstract="false" name="DebtInstrumentEarlyTerminationFee" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcyt_MeasurementInputProbabilityOfAchievementMember" abstract="true" name="MeasurementInputProbabilityOfAchievementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcyt_BusinessCombinationContingentConsiderationLiabilityPercentageInEscrow" abstract="false" name="BusinessCombinationContingentConsiderationLiabilityPercentageInEscrow" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="vcyt_NonStatutoryStockOptionsMember" abstract="true" name="NonStatutoryStockOptionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcyt_OtherNonoperatingIncomeExpenseForeignTaxCredit" abstract="false" name="OtherNonoperatingIncomeExpenseForeignTaxCredit" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcyt_BiopharmaceuticalAndOtherProvisionOfDataMember" abstract="true" name="BiopharmaceuticalAndOtherProvisionOfDataMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcyt_StockIncentivePlan2013Member" abstract="true" name="StockIncentivePlan2013Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcyt_VotingRightsForEachShareOfStock" abstract="false" name="VotingRightsForEachShareOfStock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
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  <xs:element id="vcyt_DeferredTaxAssetsOperatingLeaseLiability" abstract="false" name="DeferredTaxAssetsOperatingLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcyt_HalioDxIncMember" abstract="true" name="HalioDxIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcyt_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOfficerCompensationAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOfficerCompensationAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcyt_DecipherBiosciencesTradeNamesMember" abstract="true" name="DecipherBiosciencesTradeNamesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcyt_BusinessCombinationContingentConsiderationCashToBePaid" abstract="false" name="BusinessCombinationContingentConsiderationCashToBePaid" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcyt_BusinessCombinationIncreaseDecreaseInRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables" abstract="false" name="BusinessCombinationIncreaseDecreaseInRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="vcyt_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationNonEmployee" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationNonEmployee" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="vcyt_NanoStringMember" abstract="true" name="NanoStringMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcyt_NumberOfIntangibleAssetsAcquired" abstract="false" name="NumberOfIntangibleAssetsAcquired" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="vcyt_BusinessCombinationRecognizedIdentifiableAssetAcquiredAndLiabilityAssumedCurrentOperatingLeaseLiability" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetAcquiredAndLiabilityAssumedCurrentOperatingLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="vcyt_BusinessAcquisitionNonvestedAcquireeAwardsModified" abstract="false" name="BusinessAcquisitionNonvestedAcquireeAwardsModified" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="vcyt_IncentiveStockOptionsMember" abstract="true" name="IncentiveStockOptionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcyt_BiopharmaceuticalAndOtherMilestonesExcludingCollaborationMember" abstract="true" name="BiopharmaceuticalAndOtherMilestonesExcludingCollaborationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcyt_NoncashorPartNoncashAcquisitionDeferredPurchaseConsideration" abstract="false" name="NoncashorPartNoncashAcquisitionDeferredPurchaseConsideration" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
